Studies of sebum. 4. The estimation of squalene in sebum and sebum-like materials

Studies of sebum. IV. The estimation of squalene in sebum and sebum-like materials.

Studies of sebum. VIII. Observations on the squalene and cholesterol content and the possible functions of squalene in human sebum.

The object of our investigations has been to study the composition ofsebum and to elucidate its role in maintaining the health of the skin. In a previous paper on the hydrocarbons of sebum (Boughton, Hodgson-Jones, MacKenna, Wheatley & Wormall, 1955) we observed that the squalene content of sebum showed wide variations, both in samples collected from the same subject on different occasions and ...

Studies of Sebum. II. Some constituents of the unsaponifiable matter of human sebum.

as one of the major constituents, accounting for about 16% of the unsaponifiable matter and about 35% of the hydrocarbon fraction. Some preliminary chemical tests were made for the fatsoluble vitamins, and the presence ofa small amount of vitamin E in human sebum was reported. A more complete study of the unsaponifiable matter has now been made, and this material has been more thoroughly examin...

The possible role of squalene as a protective agent in sebum.

Human sebum contains squalene, which is a polyunsaturated triterpenoid hydrocarbon (2, 7). This substance constitutes approximately 5 per cent of skin surface sebum of the adult (2). Oxygen is taken up avidly when squalene is ex posed to air, with the rapid formation of peroxides. This fact suggested that it might function as a protective agent in sebum. It has been demon strated that it is fun...

Sebaceous-immunobiology is orchestrated by sebum lipids

The major role of sebaceous glands in mammals is to produce sebum, which coats the epidermis and the hair providing waterproofing, thermoregulation and photoprotection. However, as the need for these functions decreased along the evolutionary changes in humans, a relevant question has been raised: are sebaceous glands and sebum the remnants of our mammalian heritage or do they have overtaken a ...